<jats:title>Abstract</jats:title>
          <jats:p>This work presents a comprehensive investigation of symmetric (HJ-DD-UTFET) and asymmetric Source Drain Heterojunction Dual Dielectric Uniform Tunnel Field-Effect Transistors (A-SD-HJ-DD-UTFET) to achieve enhanced analog/RF, and linearity performance. The A-SD-HJ-DD-UTFET showcases an extremely low OFF current level of 8.124 × 10<jats:sup>–17</jats:sup> A/μm which surpasses the symmetric HJ-DD-UTFET by 5,470 times and presents a high ON–OFF ratio of 2.83 × 10<jats:sup>12</jats:sup> representing a 6,261 times improvement. This enhanced performance occurs because of structural asymmetry which makes it suitable for high-end RF and biosensing purposes while reaching a peak transconductance of 536 µS. For dengue NS1 protein detection (κ = 78.7), the TCAD-driven model of the proposed A-SD-HJ-DD-UTFET biosensor delivers a distinctive label-free detection method, achieving a peak transconductance (g<jats:sub>m</jats:sub>) of 577 µS, cut-off frequency (f<jats:sub>T</jats:sub>) of 193 GHz, Gain-Bandwidth Product (GBP) of 201 GHz, Transconductance Generation factor (TGF) of 155 V<jats:sup>-1</jats:sup>, and gain transconductance frequency product (GTFP) of 25.9 THz. These correspond to improvements of 51.4%, 13.5%, 26.4%, 96.4%, and 45.5%, respectively, over SARS-CoV spike protein detection (κ = 2). The A-SD-HJ-DD-UTFET biosensor also exhibits superior linearity performance during dengue NS1 protein detection through its desirable intercept points, minimal intermodulation distortion, and a well-maintained 1 dB compression point, affirming its potential as a high-speed, label-free RF biosensor for infectious disease Point of Care Testing (POCT) diagnostics.</jats:p>